EdenteV2, Main, Exploration, bibRecord, 000E40

Periodontal disease and breast cancer: Prospective cohort study of postmenopausal women

Identifieur interne : 000E40 ( Main/Exploration ); précédent : 000E39; suivant : 000E41

Periodontal disease and breast cancer: Prospective cohort study of postmenopausal women

Auteurs : Jo L. Freudenheim [États-Unis] ; Robert J. Genco [États-Unis] ; Michael J. Lamonte [États-Unis] ; Amy E. Millen [États-Unis] ; Kathleen M. Hovey [États-Unis] ; Xiaodan Mai [États-Unis] ; Ngozi Nwizu [États-Unis] ; Christopher A. Andrews [États-Unis] ; Jean Wactawski-Wende [États-Unis]

Source :

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [ 1055-9965 ] ; 2015.

RBID : PMC:4713270

Abstract

Background

Periodontal disease (PD) has been consistently associated with chronic disease; there are no large studies of breast cancer although oral-associated microbes are present in breast tumors.

Methods

In the Women’s Health Initiative Observational Study, a prospective cohort of postmenopausal women, 73,737 women without previous breast cancer were followed. Incident, primary, invasive breast tumors were verified by physician adjudication. PD was by self-report. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated by Cox proportional hazards, adjusted for breast cancer risk factors. Because the oral microbiome of those with PD differs with smoking status, we examined associations stratified by smoking.

Results

2,124 incident, invasive breast cancer cases were identified after mean follow-up of 6.7 years. PD, reported by 26.1% of women, was associated with increased breast cancer risk (HR 1.14, 95% CI 1.03 to 1.26), particularly among former smokers who quit within 20 years (HR 1.36; 95% CI 1.05 to 1.77). Among current smokers, the trend was similar (HR 1.32; 95% CI 0.83 to 2.11); there were few cases (n=74) and the CI included the null. The population attributable fraction was 12.06% (95% CI 1.12 to 21.79) and 10.90% (95% CI 10.31 to 28.94) for PD among former smokers quitting within 20 years and current smokers, respectively.

Conclusion

PD, a common chronic inflammatory disorder, was associated with increased risk of postmenopausal breast cancer, particularly among former smokers who quit in the past 20 years.

Impact

Understanding a possible role of the oral microbiome in breast carcinogenesis could impact prevention.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713270

DOI: 10.1158/1055-9965.EPI-15-0750
PubMed: 26689418
PubMed Central: 4713270

Affiliations:

Le document en format XML

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<author><name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name>
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<placeName><region type="state">État de New York</region>
</placeName>
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<placeName><region type="state">Texas</region>
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<wicri:cityArea>Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor</wicri:cityArea>
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<author><name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name>
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<series><title level="j">Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</title>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Periodontal disease (PD) has been consistently associated with chronic disease; there are no large studies of breast cancer although oral-associated microbes are present in breast tumors.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">In the Women’s Health Initiative Observational Study, a prospective cohort of postmenopausal women, 73,737 women without previous breast cancer were followed. Incident, primary, invasive breast tumors were verified by physician adjudication. PD was by self-report. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated by Cox proportional hazards, adjusted for breast cancer risk factors. Because the oral microbiome of those with PD differs with smoking status, we examined associations stratified by smoking.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">2,124 incident, invasive breast cancer cases were identified after mean follow-up of 6.7 years. PD, reported by 26.1% of women, was associated with increased breast cancer risk (HR 1.14, 95% CI 1.03 to 1.26), particularly among former smokers who quit within 20 years (HR 1.36; 95% CI 1.05 to 1.77). Among current smokers, the trend was similar (HR 1.32; 95% CI 0.83 to 2.11); there were few cases (n=74) and the CI included the null. The population attributable fraction was 12.06% (95% CI 1.12 to 21.79) and 10.90% (95% CI 10.31 to 28.94) for PD among former smokers quitting within 20 years and current smokers, respectively.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">PD, a common chronic inflammatory disorder, was associated with increased risk of postmenopausal breast cancer, particularly among former smokers who quit in the past 20 years.</p>
</sec>
<sec id="S5"><title>Impact</title>
<p id="P5">Understanding a possible role of the oral microbiome in breast carcinogenesis could impact prevention.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Michigan</li>
<li>Texas</li>
<li>État de New York</li>
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<tree><country name="États-Unis"><region name="État de New York"><name sortKey="Freudenheim, Jo L" sort="Freudenheim, Jo L" uniqKey="Freudenheim J" first="Jo L" last="Freudenheim">Jo L. Freudenheim</name>
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<name sortKey="Andrews, Christopher A" sort="Andrews, Christopher A" uniqKey="Andrews C" first="Christopher A" last="Andrews">Christopher A. Andrews</name>
<name sortKey="Genco, Robert J" sort="Genco, Robert J" uniqKey="Genco R" first="Robert J" last="Genco">Robert J. Genco</name>
<name sortKey="Hovey, Kathleen M" sort="Hovey, Kathleen M" uniqKey="Hovey K" first="Kathleen M" last="Hovey">Kathleen M. Hovey</name>
<name sortKey="Lamonte, Michael J" sort="Lamonte, Michael J" uniqKey="Lamonte M" first="Michael J" last="Lamonte">Michael J. Lamonte</name>
<name sortKey="Mai, Xiaodan" sort="Mai, Xiaodan" uniqKey="Mai X" first="Xiaodan" last="Mai">Xiaodan Mai</name>
<name sortKey="Millen, Amy E" sort="Millen, Amy E" uniqKey="Millen A" first="Amy E" last="Millen">Amy E. Millen</name>
<name sortKey="Nwizu, Ngozi" sort="Nwizu, Ngozi" uniqKey="Nwizu N" first="Ngozi" last="Nwizu">Ngozi Nwizu</name>
<name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name>
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</record>

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Periodontal disease and breast cancer: Prospective cohort study of postmenopausal women

Periodontal disease and breast cancer: Prospective cohort study of postmenopausal women

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